Fig. 5: HOXA5 arrests cell cycle transition from G0/G1 to S phase through cyclinD1 and p21. | Cell Death & Disease

Fig. 5: HOXA5 arrests cell cycle transition from G0/G1 to S phase through cyclinD1 and p21.

From: HOXA5 inhibits the proliferation and neoplasia of cervical cancer cells via downregulating the activity of the Wnt/β-catenin pathway and transactivating TP53

Fig. 5

a Volcano plots of the data from RNA-seq. The expression of cyclinD1 and p21 in HOXA5-modified cervical cancer cells and xenograft was determined by real-time PCR and western blot (b–e). The expression of cyclinD1 and p21 in xenograft was determined by western blot (f) and IHC (g, h). *p < 0.05, **p < 0.01, ***p < 0.001.

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