Fig. 5: IFN-γ administration improved cognitive deficits in APP/PS1 mice. | Cell Death & Disease

Fig. 5: IFN-γ administration improved cognitive deficits in APP/PS1 mice.

From: Intraperitoneal injection of IFN-γ restores microglial autophagy, promotes amyloid-β clearance and improves cognition in APP/PS1 mice

Fig. 5

a, b Learning curves of mice trained in the spatial reference version of the Morris water maze (n = 9/group). The escape latency and the distance traveled to find the hidden platform were plotted against the days of training. Each day represents the average of four consecutive training trials. Both measurements indicated that all groups significantly improved over the 5 days. *P < 0.05, **P < 0.01, ***P < 0.001 vs APP/PS1 group (two-way ANOVA with repeated measure and Bonferroni post hoc test). Specifically, the APP/PS1 group was significantly impaired compared to the other three groups at days 4 and 5 in terms of escape latency and at days 2–5 in terms of the distance traveled. c There was no difference in the speed between the APP/PS1 + IFN-γ group and the control group. *P < 0.05, ***P < 0.001 vs APP/PS1 and #P < 0.05, ##P < 0.01 vs APP/PS1 + IFN-γ (two-way ANOVA with repeated measure and Bonferroni post hoc test). d In the probe trial phase, the number of passes across the former location of the escape platform during the MWM test are shown. *P < 0.05 vs APP/PS1 (one-way ANOVA and Bonferroni post hoc test). The results are all shown as the mean ± SEM.

Back to article page