Fig. 3: Combination treatments of BH3 mimetics (S63845 plus ABT-263 or A-1331852) induced apoptosis in melanoma cell lines and patient samples. | Cell Death & Disease

Fig. 3: Combination treatments of BH3 mimetics (S63845 plus ABT-263 or A-1331852) induced apoptosis in melanoma cell lines and patient samples.

From: MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells

Fig. 3

IncuCyte live cell imaging with active Caspase 3/7 analyses to study apoptosis (a) and proliferation (b). Images were acquired using the phase and green fluorescent channels every 4 h for a total of 48 h. For visual clarity, we marked only the combinational treatments that were significantly different from comparisons with the DMSO and the single-drug treatments. Both the combination treatments significantly increased apoptosis and decreased proliferation compared to vehicle or single drugs. ***Indicates p < 0.001. Error bars represent ± SEM.

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