Fig. 8: Derepression of BRD4 contributes to SNHG18-mediated aggressive phenotype. | Cell Death & Disease

Fig. 8: Derepression of BRD4 contributes to SNHG18-mediated aggressive phenotype.

From: MKL1-induced lncRNA SNHG18 drives the growth and metastasis of non-small cell lung cancer via the miR-211-5p/BRD4 axis

Fig. 8

A Quantitative PCR analysis of BRD4 mRNA in H23 cells transfected with indicated constructs. n = 3. B Quantitative PCR analysis of BRD4 mRNA in H23 cells transfected with control siRNA (siCtrl) or 2 different BRD4-targeting siRNAs (siBRD4#1 and siBRD4#2). n = 3. C, D Assessment of C cell proliferation (n = 4) and D invasion (n = 3) in H23 cells transfected with indicated constructs. In all panels in this figure, one-way ANOVA and Bonferroni’s tests were performed. *P < 0.05. E Schematic diagram of the molecular mechanism by which MKL1-induced SNHG18 promotes NSCLC growth and metastasis through the miR-211-5p/BRD4 pathway.

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