Fig. 3: Histological analysis of the neocortex at E17.5.
From: The N-terminal BRCT domain determines MCPH1 function in brain development and fertility
A Brain weight of control (Ctr) and Mcph1-ΔBR1 (ΔBR1) mice at E17.5. B Immunostaining of Sox2 on coronal sections of control and Mcph1-ΔBR1 brain at E17.5. Right panel: Quantification of percentage of Sox2 positive cells in control and Mcph1-ΔBR1 mice. C Immunostaining of Tbr2 in control and Mcph1-ΔBR1 mice at E17.5. Right panel: Quantification of percentage of Ctip and Tbr2 positive cells in control and Mcph1-ΔBR1 mice. D Immunostaining of Ctip2 in control and Mcph1-ΔBR1 mice at E17.5. Right panel: Quantification of percentage of Ctip and Tbr2 positive cells in control and Mcph1-ΔBR1 mice. VZ: ventricular zone. SVZ: subventicular zone. IZ: intermediate zone. The number of mice used is indicated within the graph bars. Bars represent the S.D. Statistical analysis was performed by Student’s t-test. *p < 0.05; **p < 0.01; ***p < 0.001.
