Fig. 6: Blockage of ovary development and ovary tumorigenesis in Mcph1 mutant mice.
From: The N-terminal BRCT domain determines MCPH1 function in brain development and fertility
A H&E staining of ovary sections from 1-month-old control (Ctr) and Mcph1-Δ (Δ) female mice. Arrows point to follicles. B H&E staining of ovary sections from 2-month-old control and Mcph1-ΔBR1 (ΔBR1) female mice. Arrows point to follicles. C Macroscopic images of ovarian tumours of Mcph1-ΔBR1 female mice. Arrows point to ovaries. Asterisk* marks ovary tumour mass. D H&E staining of ovary sections from 12-month-old control and Mcph1-Δ mice. Histopathology revealed benign tubular adenoma. E H&E staining of ovary sections from 12-month-old controls and Mcph1-ΔBR1 mice. F The percentage of tumour incidence in control and Mcph1-ΔBR1 female mice at 12–18 months of age. The number of mice analysed is indicated within the bar.
