Fig. 8: Conditional medium (CM) from proliferating and differentiating OLs regulates microglia phagocytosis and cell morphology. | Cell Death & Disease

Fig. 8: Conditional medium (CM) from proliferating and differentiating OLs regulates microglia phagocytosis and cell morphology.

From: The immune-inflammatory response of oligodendrocytes in a murine model of preterm white matter injury: the role of TLR3 activation

Fig. 8

A Histograms reported the percentage of phagocytic cells determined as: number of cell with beads/number of total Iba1+ cells. Results are the mean of three independent experiments performed in triplicate ±SEM. B–D Microglial cell morphological changes induced by PIC or conditional medium considering cells area (B), cells perimeter (C), and cells circularity (D). Data are the mean of at least 250 cells/condition ±SEM. All comparisons were performed using One-way Anova followed by Bonferroni’s multiple comparison test. *P < 0.05 and ***P < 0.001 vs CTRL, ###P < 0,001 CM from CTRL OPCs vs CM from PIC OPCs, §§§P < 0.001 and §§P < 0.01 vs PIC, $P < 0.05 PIC CM P vs PIC CM.

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