Fig. 4: ECT2 overexpression promotes activation of AKT via the PLK1/PTEN pathway. | Cell Death & Disease

Fig. 4: ECT2 overexpression promotes activation of AKT via the PLK1/PTEN pathway.

From: ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway

Fig. 4: ECT2 overexpression promotes activation of AKT via the PLK1/PTEN pathway.

A Enrichment analysis of ECT2 pathway functions in the TCGA-LIHC cohort. B, C Western blot analysis of p-AKT, PLK1, and AKT expression levels after ECT2 knockdown or PLK1 upregulation in the HepG2 cell line. D Western blot analysis of p-AKT, PLK1, and AKT expression levels after ECT2 knockdown in the PTEN-missing cell line of HCC. E Glucose intake by cancer cells was evaluated after ECT2 knockdown. F Lactate acid production by cancer cells was evaluated after ECT2 knockdown. Error bars represent means ± SD. *p < 0.05, **p < 0.01. NS means “not significant” by paired two-sided Student’s t-test.

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