Fig. 8: Downregulation of ECT2 inhibits M2 macrophage infiltration in vivo. | Cell Death & Disease

Fig. 8: Downregulation of ECT2 inhibits M2 macrophage infiltration in vivo.

From: ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway

Fig. 8

A Weight of tumors isolated from mice with H22 injections (n = 3). B Apoptosis of tumor cells gated as mCherry+. C M2 macrophage infiltration was evaluated by flow cytometry. D NK cell infiltration was evaluated. CD107a expression is shown in the right panel. Red: control group, orange: ECT2 OE+shLDHA group, blue: ECT2 OE group. E T cell infiltration was evaluated. CD107a expression is shown in the right panel. Red: control group, orange: ECT2 OE+shLDHA group, blue: ECT2 OE group. Error bars represent means ± SD. *p < 0.05, **p < 0.01. N means “not significant” by paired two-sided Student’s t-test.

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