Fig. 6: Mypt1SMKO mice displayed glucose intolerance and impaired metabolite clearance in response to glucose challenge. | Cell Death & Disease

Fig. 6: Mypt1SMKO mice displayed glucose intolerance and impaired metabolite clearance in response to glucose challenge.

From: Acute glucose influx-induced mitochondrial hyperpolarization inactivates myosin phosphatase as a novel mechanism of vascular smooth muscle contraction

Fig. 6

A, B Fasting blood glucose (A) and serum insulin (B) in WT and Mypt1SMKO mice. n = 8. C Systolic blood pressure (SBP) and mean blood pressure (MBP) in WT and Mypt1SMKO mice. n = 8. D, E Vascular constriction in response to PE (D) and Angiotensin II (E) in isolated aortas from WT and Mypt1SMKO mice. n = 6. F, G Vascular relaxation in response to SNP (F) and ACh (G) in isolated aortas from WT and Mypt1SMKO mice. n = 6. H–J Blood glucose (H), SBP (I), and abdominal aorta diameter (J) in response to glucose challenge in WT and Mypt1SMKO mice. n = 8. K Blood glucose in response to insulin challenge in WT and Mypt1SMKO mice. n = 8. L, M Circulating 2-NBDG (L) and ICG (M) fluorescence in response to glucose challenge in WT and Mypt1SMKO mice. n = 8. *, vs. WT + saline; #, vs. WT + glucose. N The graphic summary of our findings. Error bars represent SEM. *P < 0.05. #P < 0.05. **P < 0.01.

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