Fig. 1: Pla2r1 loss increases spontaneous tumor formation in old mice.
From: PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging
A–C Macroscopic lesions of 20-month-old Pla2r1−/− mice (n = 26) and their control littermates (n = 17) were counted and analyzed histologically to characterize each lesion. A Percentage (%) of mice displaying macroscopic lesions for each genotype was calculated. P = 0.04 according to two-tailed Fisher exact test. B The mean number of lesions per mouse for each genotype was computed and presented as mean ± SEM. The p value was calculated using Mann–Whitney test. *p < 0.05. C Representative histopathological images of lesions are shown. D Indicated tumors were prepared and analyzed by immunohistochemistry against Ki67 proliferation marker to determine the percentage of positive cells. Representative images and histograms are shown (mean ± SD).
