Fig. 2: Execution of the intrinsic apoptotic pathway requires activation of BAX and BAK to form pores in the outer mitochondrial membrane resulting in mitochondrial outer membrane permeabilisation (MOMP). | Cell Death & Disease

Fig. 2: Execution of the intrinsic apoptotic pathway requires activation of BAX and BAK to form pores in the outer mitochondrial membrane resulting in mitochondrial outer membrane permeabilisation (MOMP).

From: The application of BH3 mimetics in myeloid leukemias

Fig. 2

BAX/BAK activation occurs through either the direct activation model, indirect activation model or a balance of both.

Back to article page