Table 1 Currently commercially available BH3 mimetics and related compounds are known to have been investigated in the context of hematological malignancies, with those in current and/or previous clinical trials for leukemias denoted with an asterisk (*).
Compound | Target | Published | PubMed ID |
|---|---|---|---|
ABT-737 | BCL-2, BCL-xL, BCL-w | 2005 | 15902208 |
ABT-263 (navitoclax)* | BCL-2, BCL-xL, BCl-w | 2008 | 18451170 |
ABT-199 (venetoclax)* | BCL-2 | 2013 | 23291630 |
GX15-070 (obatoclax)* | Pan-BCL-2 | 2005 | 16304385 |
WEHI-539 | BCL-xL | 2013 | 23603658 |
S1 | Pan-BCL-2 | 2011 | 20503275 |
Apogossypolone (ApoG2) | Pan-BCL-2 | 2008 | 18769131 |
BI97C1 (sabutoclax) | BCL-2, BCL-xL, A1, MCL-1 | 2010 | 20443627 |
TW-37 | BCL-2, BCL-xL, MCL-1 | 2006 | 16951185 |
BXI-61, BXI-72 | BCL-xL | 2013 | 23824742 |
JY-1-106 | BCL-xL, MCL-1 | 2013 | 23680104 |
MIM1 | MCL-1 | 2012 | 22999885 |
UMI-77 | MCL1 | 2014 | 24019208 |
Marinopyrrole A (maritoclax) | MCL-1 | 2012 | 22311987 |
A-1331852 and A1155463 | BCL-xL | 2015 | 25787766 |
A1210477 | MCL-1 | 2015 | 25590800 |
S63845 | MCL-1 | 2016 | 27760111 |
S55746 (BCL201)* | BCL-2 | 2018 | 29732004 |
ML311 (EU-5346) | MCL-1, A1 | 2012 | 23762927 |
HA14-1 | BCL-2 | 2000 | 10860979 |
2-Methoxy antimycin A3 | BCL-2, BCL-xL | 2001 | 11175751 |
AMG176* | MCL-1 | 2018 | 30254093 |
Gossypol (AT101)* | Pan-BCL-2 | 2003 | 13678404 |
AZD5991* | MCL-1 | 2018 | 30559424 |
S64315 (MIK665)* | MCL-1 | Unpublished | N/A |
A385358 | BCL-xL | 2006 | 16951189 |
VU0661013 | MCL-1 | 2018 | 30185627 |
ML311 | MCL-1 | 2013 | 23762927 |
AZD4320 | BCL-2, BCL-xL | 2019 | 29931583 |
