Fig. 1: Increased mTORC1 (pS6Ser240/244) after UNX and mTORC2 (pAktSer473) after sham surgery and UNX in the kidney is attenuated by rapamycin.
From: Surgical procedures suppress autophagic flux in the kidney
Mice underwent either no surgical manipulations (NORM), sham surgery (SHAM), or unilateral nephrectomy (UNX) and after 2 h the contralateral kidney was harvested. A Representative immunoblots and relative densitometry is shown for mTORC1 (pS6Ser240/244) and mTORC2 (pAktSer473) substrates in the kidney. *P < 0.05, **P < 0.01, ***P < 0.001. RDU = relative densitometry units corrected for GAPDH. B Representative immunoblots and relative densitometry is shown for mTORC1 (pS6) and mTORC2 (pAktSer473) substrates in the kidney after treatment of mice with rapamycin (RAPA). *P < 0.05, **P < 0.01. RDU = relative densitometry units.
