Fig. 6: Proposed model of transcriptional regulation of EphA2-SE in HeLa, HCT-116 and MCF-7 cells.

EphA2-SE interacts with the EphA2 gene promoter and promotes transcription by recruiting FOSL2 and TCF7L2, resulting in abnormally high expressionof EphA2, which activates signal pathways to promote tumor progression.