Fig. 1: The specific expression of miR-127-3p in vivo and in vitro.
From: MiR-127-3p targeting CISD1 regulates autophagy in hypoxic–ischemic cortex
A Results of miRNA sequencing analysis showed that the expression of miRNAs in sham and HI have obvious difference (n = 2/group). B The qRT-PCR validation of differential miRNAs in normal group rats and HI group rats at 12 h after HI injury. Each bar was the mean ± s.d. relative to −log2 (**P < 0.01 with Student’s t-test, n = 6). C Relative expression of miRNA-127-3p in heart, liver, brain, and kidney of rats. MiRNA-127-3p was selectively highly expressed in the brain (**P < 0.01 with one-way ANOVA, n = 6). D qRT-PCR analysis of miR-127-3p expression at 12, 48, and 96 h. MiRNA-127-3p decreased at 12 h after HI, while it increased at 48 and 96 h after HI injury (**P < 0.01 with one-way ANOVA, n = 6). E The relative expression of miR-127-3p in OGD of PC12, SY5Y, and neurons was significantly decreased in vitro (**P < 0.01 with Student’s t-test, n = 6). HI hypoxic ischemic.
