Fig. 7: Response of RBE cells expressing BF494 variations to FGFR2-selective SMKIs BGJ398 and AZD4547. | Cell Death & Disease

Fig. 7: Response of RBE cells expressing BF494 variations to FGFR2-selective SMKIs BGJ398 and AZD4547.

From: Typing FGFR2 translocation determines the response to targeted therapy of intrahepatic cholangiocarcinomas

Fig. 7

The expression of BF494, BF494-truncated, and BF494-mutation chimeras was detected by western blot with anti-Flag antibody (a). Dose-response curves for BGJ398 (b) and AZD4547 (c) in RBE cells expressing different BF494 variations. Western blotting showing phosphorylation of AKT and ERK in RBE cells expressing WT-FGFR2, BF494 truncation, BF494 mutation, or vector control (d).

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