Fig. 8: Models for the signaling transduction of fusion chimeras and targeted drugs working in the downstream of FGF signal pathway. | Cell Death & Disease

Fig. 8: Models for the signaling transduction of fusion chimeras and targeted drugs working in the downstream of FGF signal pathway.

From: Typing FGFR2 translocation determines the response to targeted therapy of intrahepatic cholangiocarcinomas

Fig. 8

Normal biological processes of FGF signal pathway (a). Sub-classical and classical chimeras lead to formation of a fusion protein consisting of a transcription factor fused to an FGFR kinase domain with consequent FGFR dimerization and activation leading to ligand-independent FGF signaling. Non-classical fusion cannot active downstream signal pathway. SMKIs suppressed the phosphorylation of FRS2, AKT, and MAPK then confer anchorage-independent growth and in vivo tumorigenesis (b). represents Ig-like domain of FGFR2, represents tyrosine kinase domain of FGFR2, represents phosphorylation, and represents stimulating target gene activity.

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