Fig. 6: Expression profile in CP patients and working model. | Cell Death & Disease

Fig. 6: Expression profile in CP patients and working model.

From: Neddylation pathway alleviates chronic pancreatitis by reducing HIF1α-CCL5-dependent macrophage infiltration

Fig. 6: Expression profile in CP patients and working model.

A Representative IHC images of UBE2M expression in CP specimens and normal tissues, and the bar graphs. B mRNA expression of UBE2M in CP specimens and normal tissues. C Western blot analysis of UBE2M in CP specimens and normal tissues. D mRNA expression of CCL5 and CD163 in UBE2Mhigh and UBE2Mlow CP specimens. E A working model depicting that inactivation of neddylation pathway by MLN4924 stabilizes HIF-1α level, upregulates CCL5 expression, accelerates macrophage infiltration, and eventually exacerbates chronic pancreatitis. A–D n = 3. Data are representative of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ns no significant.

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