Fig. 6: In vivo administration of autophagy inhibitors retarded the progression of AML. | Cell Death & Disease

Fig. 6: In vivo administration of autophagy inhibitors retarded the progression of AML.

From: Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway

Fig. 6

a Schematic representation of the experimental procedure of autophagy inhibitor treatment. As a control, mice were treated with each vehicle. b, e Total WBC count in mice treated with SBI-0206965 (b) or MRT-68921 (e) at the indicated time points. Each symbol represents an individual mouse (n = 6 or 7). c, f Percentages of GFP+CD11b+ AML cells in the PB of mice treated with SBI-0206965 (c) or MRT-68921 (f) at the indicated time points. Each symbol represents an individual mouse (n = 7). d, g Alteration of the survival rates of mice treated with SBI-0206965 (d) or MRT-68921 (g) (n = 7). **P < 0.01; *P < 0.05; N.S., no significant difference using Mann-Whitney u test or log-rank test.

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