Fig. 2: rVAR2 and V-aCD3 bind cancer cells and malignant tissue.
From: Development of a bispecific immune engager using a recombinant malaria protein
A Binding was assessed by flow cytometry. Graphs represent binding based on Geometric mean fluorescence intensity (gMFI) Flow cytometer measurements of binding to various cancer cell lines of different origins. Stippled lines show binding to VAR2, solid lines show binding to V-aCD3. The V-aCD3 and rVAR2 bound to all cancer cell lines and the antibody alone did not show any binding. B Binding of VAR2 and V-aCD3 to cancer cells are inhibited by competition with purified CSA.
