Fig. 1: Role of doxorubicin in autophagy-related cardiomyocyte death.
From: Regulated cell death pathways in doxorubicin-induced cardiotoxicity
Schematic representation of autophagy during doxorubicin treatment. Doxorubicin disrupts autophagy by: inducing initiation through AMPK activation and/or mTOR inhibition, the formation of the phagophore, upregulation of Atg proteins, and by blocking lysosomal proteolysis resulting in accumulation of autophagosomes and autolysosomes and reactive oxygen species. DOX doxorubicin, AMPK 5′ AMP-activated protein kinase, mTOR mammalian target of rapamycin, TFEB transcription factor EB, Atg autophagy-related protein, LC3II microtubule-associated protein 1A/1B-light chain 3, ROS reactive oxygen species.
