Fig. 4: Doxorubicin-induced pyroptosis.
From: Regulated cell death pathways in doxorubicin-induced cardiotoxicity
Schematic representation of doxorubicin-induced pyroptosis in the heart. Doxorubicin induces pyroptosis via the upregulation of TINCR, which recruits IGF2BP and increases the expression of NLRP3 leading to activation of caspase-1, the cleavage of GMDSD-N and the release of IL-1β, IL-18. Pyroptosis is also induced via BNIP3 activation in the mitochondria, which activates caspase 3 and causes GSDME-dependent pyroptosis. Sirtuin 1 activation inhibits NLRP3 and protects cardiomyocytes from doxorubicin-induced pyroptosis. BNIP3 BCL2 interacting protein 3, GSDMD gasdermin D, GSDME gasdermin E, TINCR terminal differentiation-induced NcRNA, IGF2BP1 insulin-like growth factor 2 mRNA-binding protein 1, NLRP3 NOD−, LRR−, and pyrin domain-containing protein 3, IL interleukin.
