Fig. 2: Plasma membrane Kv1.3 channels do not regulate proliferation or respiration. | Cell Death & Disease

Fig. 2: Plasma membrane Kv1.3 channels do not regulate proliferation or respiration.

From: Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism

Fig. 2: Plasma membrane Kv1.3 channels do not regulate proliferation or respiration.

A Whole cell voltage clamp trace showing inhibition of Kv1.3 currents by ShK-Dap22 (20 and 80 pM). B Proliferation of control HEK293 cells treated with ShK-Dap22 (1–200 pM). The percentage increase in cell number over 3 days normalised to day 0 (n = 3). C Proliferation of HEK293/Kv1.3 cells treated with ShK-Dap22 (1–200 pM). The percentage increase in cell number over 3 days normalised to day 0 (n = 4). D Routine, Leak, maximal electron transfer system (ETS) and residual (ROX) O2 consumption in HEK293/Kv1.3 cells treated with 500 pM ShK-Dap22 (n = 10). Data expressed as mean ± SEM.

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