Fig. 6: Mitochondrial Kv1.3 channels regulate proliferation and respiration via a non-conducting mechanism. | Cell Death & Disease

Fig. 6: Mitochondrial Kv1.3 channels regulate proliferation and respiration via a non-conducting mechanism.

From: Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism

Fig. 6: Mitochondrial Kv1.3 channels regulate proliferation and respiration via a non-conducting mechanism.

A Electrophysiology currents for control HEK293, HEK293/Kv1.3, HEK/Kv1.3-P89, HEK/Kv1.3-P93 and HEK293/Kv1.3-P121 when depolarised from −80 mV to +40 mV (control HEK293 cells, n = 6; HEK293/Kv1.3 cells, n = 14; HEK293/Kv1.3-P89 cells, n = 9; HEK293/Kv1.3-P93 cells, n = 15; HEK293/Kv1.3-P121 cells, n = 23). B Proliferation of control HEK293, HEK293/Kv1.3, HEK293/Kv1.3-P89, HEK293/Kv1.3-P93 and HEK293/Kv1.3-P121 cells expressed as a percentage increase in cell number over 3 days (control HEK293 cells, n = 8; HEK293/Kv1.3 cells, n = 4; HEK293/Kv1.3-P89 cells, n = 9; HEK293/Kv1.3-P93 cells, n = 6; HEK293/Kv1.3-P121 cells, n = 7). C Routine, Leak, maximal electron transfer system (ETS) and residual (ROX) O2 consumption in control HEK293, HEK293/Kv1.3 and HEK293/Kv1.3-P89 cells (control HEK293, n = 27; HEK293/Kv1.3, n = 38; HEK293/Kv1.3-P89, n = 9). D Routine, Leak, maximal ETS and ROX O2 consumption in control HEK293, HEK293/Kv1.3 and HEK293/Kv1.3-P93 cells (control HEK293, n = 27; HEK293/Kv1.3, n = 38; HEK293/Kv1.3-P93, n = 9). E Routine, Leak, maximal ETS and ROX O2 consumption in control HEK293, HEK293/Kv1.3 and HEK293/Kv1.3-P121 cells (control HEK293, n = 27; HEK293/Kv1.3, n = 38; HEK293/Kv1.3-P121, n = 6). F ATP turnover in control HEK293, HEK293/Kv1.3, HEK293/Kv1.3-P89, HEK293/Kv1.3-P93 and HEK293/Kv1.3-P121 cells (control HEK293 n = 27; HEK293/Kv1.3 n = 38; HEK293/Kv1.3-P89 n = 9; HEK293/Kv1.3-P93 n = 9; HEK293/Kv1.3-P121 n = 6). Data were mean ± SEM. Data were analysed using one-way ANOVA with Tukeys post hoc test, *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001.

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