Fig. 2: The effects of fangchinoline on the HR pathway in CM-AS16 cells were determined by transcriptome analysis and qRT-PCR. | Cell Death & Disease

Fig. 2: The effects of fangchinoline on the HR pathway in CM-AS16 cells were determined by transcriptome analysis and qRT-PCR.

From: Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway

Fig. 2: The effects of fangchinoline on the HR pathway in CM-AS16 cells were determined by transcriptome analysis and qRT-PCR.

A KEGG enrichment analysis of DEGs altered by 8 μM fangchinoline. All pathways significantly enriched in the DEGs (adjusted P < 0.01) were included. B A heat map depicting DEGs altered by fangchinoline revealed a significant correlation with the HR pathway. The colour indicates the relative gene expression value. Blue: lowest expression; red: highest expression. C Quantification of the relative expression of genes related to the HR pathway. Data represent the mean ± SD of four independent experiments. *P < 0.05, ****P < 0.0001, by Student’s t-test.

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