Fig. 4: Invasive phenotypes of PTEN edge mutants are not altered by BKM120, a PI3K/Akt inhibitor. | Cell Death & Disease

Fig. 4: Invasive phenotypes of PTEN edge mutants are not altered by BKM120, a PI3K/Akt inhibitor.

From: Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma

Fig. 4

A Development of invasive branches in PTEN-null PDCs (P090) overexpressing PTEN edge mutation was not altered by BKM120, a pan-PI3K inhibitor (p-value = <0.001, 0.091, 0.071, and 0.193 for NT, H93Y, C124S, and R130Q, two-sided t test). Data are shown as the means of four experimental replicates ± s.d. B, C Persistence of PTEN edge mutants at the cellular edge of U87MG cells and PTEN-null PDCs (P089) with exogenous edge mutation following BKM120 treatment. NT, null-type; del, deletion; conc., concentration.

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