Fig. 6: Radiographic failure patterns of GBM tumors with PTEN edge mutations.
From: Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma
A Representative MR images depicting the locally invasive failure pattern of GBM tumors with PTEN edge mutation. Two GBM patients with PTEN edge mutation R130Q demonstrated locally invasive failure patterns, with tumors transmitted to the contralateral hemisphere in a locally invasive, infiltrative manner. B Distribution of radiographic recurrence patterns in CLUM-defined clusters. Edge mutations were included in cluster 4, while, the nuclear mutation was included in cluster 1 with other mutations in the C2 domain. LMC, leptomeningeal seeding.
