Fig. 2: Simvastatin increased SOD1 aggregation in SOD1G93A mice. | Cell Death & Disease

Fig. 2: Simvastatin increased SOD1 aggregation in SOD1G93A mice.

From: Simvastatin accelerated motoneurons death in SOD1G93A mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles

Fig. 2

A Western blot analysis of SOD1 levels in the lumbar spinal cord at 120 days. Quantitative analysis of SOD1 levels. B Immunofluorescence labeling of SOD1 (green) in the lumbar spinal cord at 120 days (Scale bars, 50 μm). Quantification of SOD1 immunoreactivity. C Colocalization of SOD1 (red) and P62 (green) in MNs of G93A-Sim and G93A-Con mice at 120 days (Scale bars, 10 μm). D Representative Western blot quantification of P62, LC3, and SOD1 levels in the lumbar spinal cord of G93A-Sim and G93A-Con mice at 90 days, 120 days, and end-stage of disease. (Data represent the mean ± SEM, n = 5 mice per group; statistical significance was assessed by one-way ANOVA or an unpaired t-test, #P ≤ 0.05, ##P ≤ 0.01, ###P ≤ 0.001).

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