Fig. 1: FCN3 is down-regulated in LUAD. | Cell Death & Disease

Fig. 1: FCN3 is down-regulated in LUAD.

From: FCN3 functions as a tumor suppressor of lung adenocarcinoma through induction of endoplasmic reticulum stress

Fig. 1: FCN3 is down-regulated in LUAD.

A Box-plots of FCN3 RNA expression in normal-tumor matched 102 LUAD patients in this study (left panel) and of normal-tumor matched 58 patients from TCGA data (right panel). The bold line in the middle of each box represents the median level. B Conventional RT-PCR confirmation using normal (N) and tumor (T) tissue samples from 5 representative LUAD patients. ACTB was used as an endogenous reference gene. Note that mRNA expression of FCN3 is markedly down-regulated in tumor tissues. NTC stands for no template control. C Immunoblot analysis of FCN3 expression in normal (N) and tumor (T) tissue samples of 4 representative patients. ɑ–Tubulin was used as the loading control. FCN3 down-regulation is confirmed. D Kaplan–Meier survival curves of 58 TCGA LUAD patients divided into two groups based on FCN3 expression. Long-term survival was seen to be significantly correlated with high expression of FCN3.

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