Fig. 2: Cell growth is inhibited by FCN3. | Cell Death & Disease

Fig. 2: Cell growth is inhibited by FCN3.

From: FCN3 functions as a tumor suppressor of lung adenocarcinoma through induction of endoplasmic reticulum stress

Fig. 2: Cell growth is inhibited by FCN3.

A A549 and H23 cells were transduced with control empty virus (EV), FCN3-expressing virus, or CDKN2A-expressing virus and allowed to grow for 8 and 12 days, respectively. Resulting colonies were stained with Coomassie blue, and the number was determined. Graphs to the right show result from three independent experiments as mean ± SEM. Note the strong decrease in the number of colonies in FCN3-expressing cells. B Photographs of mice with xenograft tumors (top) and of excised tumors (bottom). The mice were sacrificed 35 days after cell injection. Note that tumors from the FCN3-expressing A549-injected group show decreased tumor development compared to mice in the control group injected with control EV-transduced A549 cells. C Growth curves of xenograft tumor. Tumor volume was measured every 5 days. N = 10 for both groups. D Body weight of BALB/c nude mice was measured every 5 days. E The weight of all tumors isolated from EV group and FCN3 group. The lines in the middle represent the median levels. (**) and (***) represent P-values of <0.01 and <0.001 from t tests, respectively.

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