Fig. 1: The correlation between HIF-1α or NRP1 expression as well as VM and the clinicopathological parameters and prognosis of patients with LUAD. | Cell Death & Disease

Fig. 1: The correlation between HIF-1α or NRP1 expression as well as VM and the clinicopathological parameters and prognosis of patients with LUAD.

From: HIF-1α promoted vasculogenic mimicry formation in lung adenocarcinoma through NRP1 upregulation in the hypoxic tumor microenvironment

Fig. 1

A LUAD specimens were analyzed by immunohistochemistry. The upper panel shows negative expression, and the middle panel shows positive expression of HIF-1α and NRP1. The lower panel represents VM (×200, scale bars, 100 µm). The red arrows indicate VM channels, which are characterized by PAS+CD34− tumor cells, and the green arrows indicate EDVs, which are characterized by PAS+CD34+ tumor cells. B, C Kaplan–Meier analysis of the overall survival of patients with HIF-1α-high and HIF-1α-low samples, NRP1-high and NRP1-low samples, and VE-cadherin-high and VE-cadherin-low samples.

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