Fig. 5: Knocking down MTF-1 by siRNA strategy reverted RLIP-induced upregulation of NCX1. | Cell Death & Disease

Fig. 5: Knocking down MTF-1 by siRNA strategy reverted RLIP-induced upregulation of NCX1.

From: The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke

Fig. 5: Knocking down MTF-1 by siRNA strategy reverted RLIP-induced upregulation of NCX1.

Representative Western blot of NCX1 in the cortex of rat: (i) sham-operated (CTL), (ii) exposed to tMCAO and icv-injected with a non targeting siRNA (tMCAO+siCTL) or a siRNA for MTF-1 (tMCAO+siMTF-1) and; (iii) to tMCAO+FAO icv-injected with a non targeting siRNA (tMCAO+siCTL+FAO) or a siRNA for MTF-1 (tMCAO+siMTF-1+FAO). *p < 0.05 vs. CTL by one-way ANOVA followed by Bonferroni test. Each column represents the mean ± SEM (n = 4/5).

Back to article page