Fig. 1: MTA2 expression in human cervical cancer cells and its correlation with MMP12 and cervical cancer lung metastasis. | Cell Death & Disease

Fig. 1: MTA2 expression in human cervical cancer cells and its correlation with MMP12 and cervical cancer lung metastasis.

From: MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1/MEK3/p38/YB1 axis

Fig. 1

(A) Protein level of MTA2 and MMP12 in human cervical cancer cells as determined by Western blot. (B) mRNA expression of MTA2 and MMP12 in human cervical cancer cells as determined by qRT-PCR. (C) Protein level of MTA2 and MMP12 in MTA2-knockdown HeLa and SiHa cells as determined by Western blot. (D) mRNA expression of MTA2 and MMP12 in MTA2-knockdown HeLa and SiHa cells as determined by qRT-PCR. (E–H) MTA2-knockdown cells were subjected to in vivo xenograft analysis for assessment of (E) lung metastasis, (F) numbers of lung nodules, (G) weights of lungs, and (H) histological change in lung tissues as indicated by IHC staining. **P < 0.01 compared with the shLuc cells or shLuc-group.

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