Fig. 4: Involvement of ASK1 and MEK3 in p38-governed downregulation of MMP12 in MTA2-knockdown cervical cancer cells. | Cell Death & Disease

Fig. 4: Involvement of ASK1 and MEK3 in p38-governed downregulation of MMP12 in MTA2-knockdown cervical cancer cells.

From: MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1/MEK3/p38/YB1 axis

Fig. 4: Involvement of ASK1 and MEK3 in p38-governed downregulation of MMP12 in MTA2-knockdown cervical cancer cells.

(A, B) Cells were transfected with shRNA against MTA2 (shMTA2) and siRNA against MEK3 (si-MEK3) and then subjected to (A) migration and invasion assay or (B) immunodetection of MTA2, MEK3, p38, and MMP12. (C, D) Cells were transfected with shRNA against MTA2 (shMTA2) and siRNA against ASK1 (si-ASK1) and then subjected to (C) migration and invasion assay or (D) immunodetection of MTA2, ASK1, MEK3, p38, and MMP12. β-actin signal was used as internal control. ** and #, P < 0.01 and P < 0.05 compared with shLuc and shMTA2 cells alone, respectively.

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