Fig. 7: The working model depicting the role of TRIM25 in CRC cells.
From: TRIM25 regulates oxaliplatin resistance in colorectal cancer by promoting EZH2 stability
TRIM25 stabilizes EZH2 by blocking TRAF6-mediated ubiquitination for EZH2 degradation, and sustains stem cell properties to promote the resistance of CRC to OXA.
