Fig. 7: Schematic model showing how HSPB3 participates to myoblast differentiation.
From: Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor
The replacement of the LBR-tether with the LMNA-tether remodels transcription to induce differentiation-specific genes upon myoblast differentiation. HSPB3 assists nuclear and chromatin remodeling during myoblast differentiation by targeting LBR (upper panel). Deregulation of this HSPB3 specialized function, due to gene silencing or disease-linked mutation (R116P-HSPB3), compromises myoblast differentiation, with potential implications for human neuromuscular diseases (lower panel).
