Fig. 1: Adipor1 expression in the retina. | Cell Death & Disease

Fig. 1: Adipor1 expression in the retina.

From: ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss

Fig. 1

A–D In situ hybridization. Adipor1 mRNA was prominently expressed in the PISs (arrowhead) and weakly in the inner retinal layers of WT mouse retina at 4 weeks of age (A). No signals were recorded with the antisense probe in the Adipor1 KO retina (B) or the sense probe in the WT retina (C). Note that retinal thinning had already begun in the KO mice at this time point (see Fig. 3 for details). Adipor1 mRNA was also expressed in the RPE (arrowhead) as shown in BALB/c albino retinas (D). E, F Real-time PCR. Adipor1 mRNA increased during retinal development, peaking at 3 weeks of age in the neural retina (E) and at 5 weeks of age in the RPE (F). GCL ganglion cell layer, INL inner nuclear layer, IPL inner plexiform layer, ONL outer nuclear layer, OPL outer plexiform layer, PIS photoreceptor inner segment, POS photoreceptor outer segment, RPE retinal pigment epithelium. Data are shown as means ± standard deviations. n = 5, **P < 0.01 vs. P3, one-way ANOVA.

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