Fig. 4: MDSCs are capable of inducing PD-1−PD-L1 B cells in vivo+. | Cell Death & Disease

Fig. 4: MDSCs are capable of inducing PD-1−PD-L1 B cells in vivo+.

From: Myeloid-derived suppressor cells regulate the immunosuppressive functions of PD-1−PD-L1+ Bregs through PD-L1/PI3K/AKT/NF-κB axis in breast cancer

Fig. 4

Normal mice were intravenously injected with congenic tumor-derived MDSCs (3 × 107) every 2 days (n = 5). Normal mice were injected with PBS and used as the control group. After 1 week, the proportions of MDSCs (a) and PD-1−PD-L1+ B cells (b) in the spleen, peripheral blood, and bone marrow were measured by FC. (In all experiments, Bar graphs and plots represent or include mean ± SD, respectively. ns no statistically significant, ***p < 0.001).

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