Fig. 7: Schematic representation of the MDSCs regulation on B cells in breast cancer. | Cell Death & Disease

Fig. 7: Schematic representation of the MDSCs regulation on B cells in breast cancer.

From: Myeloid-derived suppressor cells regulate the immunosuppressive functions of PD-1−PD-L1+ Bregs through PD-L1/PI3K/AKT/NF-κB axis in breast cancer

Fig. 7

Breast cancer-derived MDSCs regulate the immunosuppressive functions of PD-1−PD-L1+ B cells through PD-L1/PI3K/AKT/NF-κB axis. Anti-PD-1 Abs, LY294002, and BAY 11-7085 can reverse MDSC-educated B cell-mediated inhibition of the T cell immune response+.

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