Fig. 5: Reduction of autophagy at 8 weeks after TAC by genetic deletion of RAGE or an autophagy inhibitor (3-MA or CQ). | Cell Death & Disease

Fig. 5: Reduction of autophagy at 8 weeks after TAC by genetic deletion of RAGE or an autophagy inhibitor (3-MA or CQ).

From: Knockout RAGE alleviates cardiac fibrosis through repressing endothelial-to-mesenchymal transition (EndMT) mediated by autophagy

Fig. 5

A Representative autophagic ultrastructure of the heart tissue under transmission electron microscopy (Scale bars = 2 µm; arrow: autolysosome). B Quantification of autophagy lysosomes analysis. C–F Left ventricular levels of RAGE and autophagy-related proteins (LC3BII/I and Beclin 1) were assessed by western blot. Quantification of RAGE (D), Beclin 1 (E), and LC3BII/I (F). GAPDH was used as the internal control. n = 6. Data are presented as mean ± SEM. *p < 0.05 vs. sham group, #p < 0.05 vs. TAC group.

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