Fig. 6: AGEs-RAGE induced EndMT by mediating endothelial autophagy in HUVECs. | Cell Death & Disease

Fig. 6: AGEs-RAGE induced EndMT by mediating endothelial autophagy in HUVECs.

From: Knockout RAGE alleviates cardiac fibrosis through repressing endothelial-to-mesenchymal transition (EndMT) mediated by autophagy

Fig. 6

A Confocal microscopic image of double immunofluorescence staining for CD31 (green) and α-SMA (red); nuclei were counter stained with DAPI (blue); (Scale bars = 100 µm). B Protein expression of Beclin 1, LC3BII/I, RAGE, Collagen I, N-Cadherin, VE-Cadherin, CD31, and α-SMA assessed by western blotting. Quantification of RAGE (C), COL I (D), N-Cadherin (E), VE-Cadherin (F), CD31 (G), α-SMA (H), Beclin 1 (I), and LC3BII/I (J). GAPDH was used as the internal control. n = 6. Data are presented as mean ± SEM. *p < 0.05 vs. control group.

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