Fig. 8: FIP1 KD alleviates IRI-induced inflammation activation, oxidative stress, and apoptosis. | Cell Death & Disease

Fig. 8: FIP1 KD alleviates IRI-induced inflammation activation, oxidative stress, and apoptosis.

From: Alternative polyadenylation trans-factor FIP1 exacerbates UUO/IRI-induced kidney injury and contributes to AKI-CKD transition via ROS-NLRP3 axis

Fig. 8: FIP1 KD alleviates IRI-induced inflammation activation, oxidative stress, and apoptosis.

A Schematic diagram demonstrating the animal experiment design. B The representative of HE staining and IHC staining for NLRP3, CD11b, and F4/80 in kidney specimens from the indicated group of mice (n = 5 per group). C Quantitative analysis of IHC staining for NLRP3, CD11b, and F4/80 in kidney specimens from the indicated group of mice. D Representative images and quantitative analysis of TUNEL staining in kidney specimens from the indicated group of mice. E Representative images and quantitative analysis of DHE staining in kidney specimens from the indicated group of mice. F Quantitative analysis of MDA (left) and SOD (right) of mice from the indicated group. G Proposed model of FIP1-induced kidney injury progression and AKI-CKD transition. P < 0.05; **P < 0.01; ***P < 0.001; All data represent the mean ± SEM obtained from three independent experiments. Student’s t test.

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