Fig. 5: Mitophagic flux is independent of Drp1. | Cell Death & Disease

Fig. 5: Mitophagic flux is independent of Drp1.

From: Mitochondrial fission and mitophagy are independent mechanisms regulating ischemia/reperfusion injury in primary neurons

Fig. 5

A Representative images of Drp1fl/fl/QCKi/+ primary cortical neurons, infected with either LV-EF1a-empty or LV-EF1a-cre, subjected to OGD/R and analyzed for the presence of mCherry puncta. B Quantification of mCherry puncta per cell and total LAMP1 puncta per cell during OGD/R. Two-way ANOVA was used to detect differences across time and between conditions. Multiple comparisons across time were assessed by comparing the means of each time point with the mean of the control and were calculated using Dunnett’s post-hoc analysis. Multiple comparisons between conditions were computed using Sidak’s post-hoc analysis. *p < 0.05; **p < 0.01 across time, #p < 0.05 between condition, n = 8 biological replicates per group. Scale bar = 10 µm.

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