Fig. 2: SGLT1 promotes glycolysis in tamoxifen-resistant breast cancer cells. | Cell Death & Disease

Fig. 2: SGLT1 promotes glycolysis in tamoxifen-resistant breast cancer cells.

From: Sodium/glucose cotransporter 1-dependent metabolic alterations induce tamoxifen resistance in breast cancer by promoting macrophage M2 polarization

Fig. 2: SGLT1 promotes glycolysis in tamoxifen-resistant breast cancer cells.

A Glucose uptake in MCF7, MCF7-TAMR1, SGLT1 knockdown in MCF7-TAMR1, and SGLT1-overexpressing MCF7 cells as determined by the 2-NBDG assay. MFI median fluorescence intensity (***P < 0.001 vs. MCF7; ###P < 0.001 vs. MCF7-TAMR1). B, C ECAR AUC (B) and lactic acid production (C) in MCF7, MCF7-TAMR1, SGLT1 knockdown in MCF7-TAMR1, and SGLT1-overexpressing MCF7 cells (*P < 0.05, **P < 0.01 vs. MCF7; #P < 0.05 vs. MCF7-TAMR1).

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