Fig. 2: Beraprost promotes the regeneration of bone defects.
From: Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination
A Representative images of micro-CT reconstruction of femoral cortical bone defects. B–D Histomorphometric analysis of the regenerated bone. The mean values of the bilateral defects of each mouse were counted as individual data points. Results are shown as mean ± SD; n = 5; **P < 0.01, ***P < 0.001 by ANOVA with Tukey’s post-hoc test. E–H Quantitative analyses of micro-CT of distal femurs. Results are shown as mean ± SD; n = 5; **P < 0.01, ***P < 0.001 by ANOVA with Tukey’s post-hoc test. I, J Serum concentration of β-CTX and P1NP. Results are shown as mean ± SD; n = 5; *P < 0.05, ***P < 0.001 by ANOVA with Tukey’s post-hoc test. K H&E staining of femoral bone defects. L Representative images of immunohistochemical staining of Runx2. Scale bar, 20 µm. M, N Representative images of ALP and TRAP staining. Scale bar, 20 µm. O, P Quantification of Alp and TRAP staining. Results are shown as mean ± SD; n = 5, *P < 0.05, **P < 0.01 by ANOVA with Tukey’s post-hoc test.
