Fig. 2: OTUD7B is overexpressed in breast cancer and correlates with poor prognosis.
From: OTUD7B stabilizes estrogen receptor α and promotes breast cancer cell proliferation
A–G Expression of OTUD7B in breast cancer. A–D: Patients were extracted from TCGA BRCA dataset. E–G: Patients were extracted from microarray datasets. All data are available at bc-GenExMiner v4.5(http://bcgenex.centregauducheau.fr/BC-GEM/GEM-Accueil.php?js=1). The significance of differences was calculated using one-way ANOVA test. H, I OTUD7B is associated with poor overall survival and relapse-free survival of breast cancer patients in TCGA. Cox proportion hazards model was used to understand the significance between two groups. J, K OTUD7B was associated with poor relapse-free survival and distant metastasies-free survival of ERα-positive breast cancer patients in GSE6532. Cox proportion hazards model was used to clarify the significance between two groups. L–N Correlations between OTUD7B and ERα target genes in TCGA (Pearson correlation). O Correlations between OTUD7B and ERα protein levels in CPTAC (Pearson correlation). *P value < 0.05, **P value < 0.01, ***P value < 0.001.
