Fig. 4: Reduced mobilization and recruitment of monocytic MDSCs by knockout of CXCL10/TLR4 in mouse IRH model. | Cell Death & Disease

Fig. 4: Reduced mobilization and recruitment of monocytic MDSCs by knockout of CXCL10/TLR4 in mouse IRH model.

From: Monocytic MDSC mobilization promotes tumor recurrence after liver transplantation via CXCL10/TLR4/MMP14 signaling

Fig. 4

A Less circulatory and hepatic monocytic MDSCs in CXCL10−/− mice compared to wild-type ones. B Significantly decreased mobilization and recruitment of monocytic MDSCs in TLR4−/− mice. C No significant change of circulatory and hepatic monocytic MDSCs by knockout of CXCR3. D Reduced TLR4+ monocytic MDSCs in the circulation and liver of CXCL10−/− mice compared to wild-type ones after IRH. N = 5/group; Error bars indicate Standard Error of Mean; *p < 0.05, **p < 0.01. MDSC myeloid-derived suppressor cell, IRH ischemia/reperfusion plus major hepatectomy, WT wild type.

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