Fig. 2: High glucose induces (5.6, 12.5, 25, and 50 mM) oxidative stress and suppresses AMPK signaling in chondrocytes. | Cell Death & Disease

Fig. 2: High glucose induces (5.6, 12.5, 25, and 50 mM) oxidative stress and suppresses AMPK signaling in chondrocytes.

From: High glucose suppresses autophagy through the AMPK pathway while it induces autophagy via oxidative stress in chondrocytes

Fig. 2

A Representative micrographs of DCFH-DA staining representing the levels of ROS in chondrocytes. Scale bar = 50 μM. B DCFH-DA fluorescence intensity of chondrocytes treated with various glucose concentrations. C Expression and quantification analyses of p-AMPK and AMPK in chondrocytes treated with various glucose concentrations. D Expression of p-AMPK/AMPK under various glucose concentrations. Data are presented as means ± SD (n = 5). *P < 0.05, **P < 0.01, and ***P < 0.001.

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