Fig. 1: The frequent downregulation of CBX7 correlates with poor prognosis in UBC patients.
From: CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10–ERK signaling
a Hierarchical clustering illustrates the expression of CBX genes in TCGA-BLCA between UBC tissues and the adjacent normal tissues. b, c CBX7 mRNA expression between UBC tissues and the adjacent normal tissues in TCGA-BLCA and GSE13507. d–g The association of CBX7 mRNA expression with clinicopathologic features in TCGA-BLCA and GSE13507. h CBX7 mRNA expression in five UBC subtypes. i, j Kaplan–Meier plot of overall survival of UBC patients in TCGA-BLCA and GSE13507. k, l CBX7 protein levels in 16 paired UBC tissues (T) and their adjacent noncancerous tissues (N) were detected by western blotting. m IHC staining of CBX7 expression in a section containing UBC tissues and its tumor-adjacent noncancerous tissues. Scale bar, 200 μm (upper panel); 20 μm (lower panel). n Kaplan–Meier survival plot for CBX7 was constructed according to the IHC staining score. o Endogenous expression of CBX7 in a nonmalignant normal urothelial cell line and multiple human UBC cell lines by western blotting. Data are presented as means ± SD. ***p < 0.001.
